Guin Saga is a popular series of Japanese novels with 130 volumes. Yes, you read that right. The series is the largest novel ever written. Its popularity lead to subsequent manga and an anime series.
Why I mention it here is because the title character is a very studly warrior who has been cursed to possess the head of a leopard. The character also possesses the strength and cunning of a predator cat, but has no idea how he came to have such abilities. It is rare to find a sexy manimal as the main subject of any work, let alone one as popular as this series.
The first year of the anime series is available on Hulu.